Endocrine Abstracts

Objectives: Assess the dose of levothyroxine in relation to TSH and FT4 at diagnosis of AHT in children with SH and OH.Methods: Two hundred one children (155 girls) with AHT were devided according to TSH and FT4 levels at diagnosis of hypothyroidism [SH-FT4 >1.0 ng/dl: Group 1: TSH: 5–7.5 mU/l, Group 2: TSH: >7.5 mU/l, OH: Group 3: TSH>7.5 mU/l and FT4 ≤1.0 ng/dl]. Mean L-T4 dose was reported in μg/Kg per day at diagnosis and ...

Introduction: Across different chronic diseases, it has been shown that problem focused coping is associated with better adjustment. The aim of the study was to evaluate the various coping behaviors of children and adolescents with type 1 diabetes (T1DM) and their association with metabolic control and duration of disease.Methods: The study population consisted of 65 children and adolescents with T1DM (male/female: 22/43) with a mean (±S.D.</...

Obese children frequently present with accelerated growth and early puberty.Objective: To examine the degree of bone maturation in children with simple obesity.Patients and methods: One hundred eighteen boys with mean chronological age (CA) 9.9±2.2 years (3–13 years) and 102 girls with CA 8.4±2.0 years (3–12 years) with simple obesity (BMI>97th centile for age and sex) were studied. Ninety-five children were...

Rathke cleft cysts (RCCs) are non-neoplastic sellar lesions derived from remnants of Rathke’s pouch, and mostly asymptomatic. Symptomatic RCCs occur usually in middle-age, are >1 cm, and cause pituitary hypofunction, diabetes insipidus, hyperprolactinemia or visual impairment. In children, RCCs are rare and usually asymptomatic. However, symptomatic cases may present with growth retardation and diabetes insipidus. We report two children with symptomatic RCC manifestin...

Pheochromocytomas and paragangliomas, tumors originating from the chromaffin cells, are rare in children.We report an 8-year-old boy who was admitted to the intensive care unit with seizures for which the child had to be intubated, severe hypokalemia (1.8 mEq/l), hyponatremia (127 mEq/l) and fever. Parents reported that several months before admission the boy had nocturnal sweating. Brain MRI revealed areas of increased sign intensity in the parietal lob...

Aim: To estimate the impact of overconsumption of salty and sweet foods on Body Mass Index (BMI) and Blood Pressure (BP) in children.Patients-Methods: We studied 208 children (105 girls), aged 9.2±3.0 yr, 57 (27.4%) of normal weight, 37 (17.8%) overweight and 114 (54.8%) obese. Overconsumption of NaCl was considered >5 g/day and of free sugar >0.5 g/Kg ideal Body Weight/day. BP was measured as appropriate and BMI was estimated in all childre...

Aim: To study the effect of thyroxine treatment on the size of thyroid nodules in children with Hashimoto’s thyroiditisPatients and methods: Twenty-two girls and 6 boys (78.6/21.4%) were followed for 2 years under thyroxine therapy, at mean dose 1.6±0.4 μg/kg per day. Diagnosis of Hashimoto’s thyroiditis was based on the high value of either antithyroid antibodies, ATPO or ATG. Age at presentation was 10.6±2.0 year (6.2–13.6...